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  1. Professionals

Karalena Guerrieri Senese

Partner

Chicago

+1 312-558-8079

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  • Overview
  • Experience
  • Credentials
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Karalena is a litigator who concentrates her practice on complex commercial and patent litigation. She has experience representing clients in all phases of litigation, including trial and appeal, in both state and federal court.

Karalena has experience in all phases of trial litigation, including developing claims and defenses, taking and defending depositions, drafting dispositive motions, and preparing expert witnesses for trial. Karalena focuses her intellectual property practice on pharmaceutical patent litigation and has represented pharmaceutical clients from pre-suit strategy development through trial and appeal. She has been an integral member of several trial teams and specializes in preparing subject-matter experts for trial. In her appellate practice, Karalena has briefed appeals to the Federal, Fifth, and Eleventh Circuits, as well as pro bono appeals to the Illinois Appellate and Supreme Courts. Karalena regularly counsels her clients on complex legal questions by relying on thorough research and analysis to develop creative solutions to meet their needs.

Key Matters

Examples of Karalena’s experience include: 

  • Represented FieldTurf, USA, Inc., in a jury trial in Cook County, Illinois. 
  • Represented pharmaceutical clients in bench trials in the District of Delaware and the District of New Jersey. 
  • Briefed a successful motion to dismiss on consumer fraud and RICO claims against a client in the insurance industry. 
  • Contributed to a successful motion to dismiss on employment discrimination claims and appellate briefing that resulted in affirmance by the Fifth Circuit. 
  • Represented generic pharmaceutical and biosimilar clients in litigation involving products such as Axiron®(testosterone), Oracea®(doxycycline), Ovide®(malathion), Enbrel®(etanercept), Remicade®(infliximab), Otezla®(apremilast), and Latuda®(lurasidone). 

  • Best Lawyers: Ones to Watch in America®
    •  Commercial Litigation, 2024–2025
    • Mass Tort Litigation / Class Actions - Defendants, 2025

Karalena is actively involved in the firm’s associate training program and presents annual training curriculum for incoming associates.

Karalena is active in the firm’s pro bono program. Her recent pro bono matters include representing a family fleeing gang and domestic violence in asylum proceedings and helping a special needs student obtain adequate services from Chicago Public Schools.

Capabilities

Litigation/Trials
Product Liability & Mass Torts
Intellectual Property
Medical Devices

Key Matters

Examples of Karalena’s experience include: 

  • Represented FieldTurf, USA, Inc., in a jury trial in Cook County, Illinois. 
  • Represented pharmaceutical clients in bench trials in the District of Delaware and the District of New Jersey. 
  • Briefed a successful motion to dismiss on consumer fraud and RICO claims against a client in the insurance industry. 
  • Contributed to a successful motion to dismiss on employment discrimination claims and appellate briefing that resulted in affirmance by the Fifth Circuit. 
  • Represented generic pharmaceutical and biosimilar clients in litigation involving products such as Axiron®(testosterone), Oracea®(doxycycline), Ovide®(malathion), Enbrel®(etanercept), Remicade®(infliximab), Otezla®(apremilast), and Latuda®(lurasidone). 

Credentials

Education

Karalena received her J.D., cum laude, from the University of Michigan Law School, where she served as editor-in-chief of the Michigan Journal of Gender and Law and co-chair of the Family Law Project. She graduated magna cum laude from Loyola University Chicago in 2011, with a B.A. in Journalism and a B.A. in International Studies.

    Admissions
    • Illinois

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    Capabilities

    Litigation/Trials
    Product Liability & Mass Torts
    Intellectual Property
    Medical Devices
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